In the movie, I am Legend, Will Smith plays a virologist who is also the protagonist of the film. In the film he creates a vaccine to protect himself from a virus that turns people into zombie/vampire/ghoul things. This may sound like something that is possible but it actually wouldn't work in real life. In the movie it is known that he is the only human that is currently "living" in the city, so knowing this and knowing that to make a vaccine, you would need a patient that had this disease already to get a small cell of the virus which you could then genetically modify so that it was weak and couldn't reproduce rapidly. So to create this vaccine that would protect him so much, he would either need to find another human that would contact or already had contacted the virus and take some of their blood, or he could get the virus and then take his own blood and then he would have something that scientists could go off of because it surely wouldn’t be perfect enough to keep everyone from contacting the virus.
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