From playing the Pandemic game, I can say that a disease being resistant to the heat, the cold, and moisture is a good way for it to spread and if the symptoms include coughing or sneezing than it can be spread easily. It if can be spread through the air, water, insects, and/or rodents than it is going to infect a lot of people.
Also, I did the disease Epidemic Typhus in the Class Spreadsheet.
Notes are here: https://docs.google.com/document/d/1_VfCl_B4eVlweS0hpoD_xD0qVQb-CppMYjZXjxk2EDI/edit?usp=sharing
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